Pristane-Induced Lupus Oil Pristane: Implications for Induction of Apoptosis by the Hydrocarbon
نویسندگان
چکیده
منابع مشابه
Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is accompanied by the emergence of autoreactive T cells and a reduction in regulatory T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted NK T cells, suggesting a role for these cells in the regulation of SLE. In this study, we show that CD1d deficiency exacerbates lupus nephritis induced by the hydro...
متن کاملImmunopathogenesis of environmentally induced lupus in mice.
Systemic lupus erythematosus (SLE) is a systemic autoimmune syndrome defined by clinical and serologic features, including arthritis, glomerulonephritis, and certain autoantibodies such as anti-nuclear ribonucleoprotein (nRNP)/Smith antigen (Sm), DNA, and ribosomal P. Although lupus is considered primarily a genetic disorder, we recently demonstrated the induction of a syndrome strikingly simil...
متن کاملBaicalin Ameliorates Dysimmunoregulation in Pristane-Induced Lupus Mice: Production of IL-6 and PGE2 and Activation of T cells
− Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by abnormalities in T cell immunoregulation and hyperreactivity of B cells, leading to autoantibody production and multiorgan injuries. We investigated the effect of baicalin on aberrant immunoregulation in pristane-induced lupus mice. Mice received i.p. a single injection of 0.5 ml of pristane or P...
متن کاملAutoimmunity Induced by Hydrocarbon Oils in Mice
For many decades, mineral oils with or without dried mycobacteria, i.e. Complete and Incomplete Freund ́s Adjuvant, have been the most commonly used immune adjuvants for experimental work. Later on, better defined hydrocarbon oils such as pristane (2,6,10,14-tetramethylpentadecane), squalene (2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosa-hexane), or hexadecane have emerged and partially r...
متن کاملInduction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane
Intraperitoneal injection of pristane (2,6,10,14 tetramethylpentadecane) is a standard technique for obtaining monoclonal antibody-enriched ascitic fluid. However, pristane also induces plasmacytomas and an erosive arthritis resembling rheumatoid arthritis in BALB/c mice, probably as a consequence of enhanced interleukin 6 production. We report here that the production of autoantibodies charact...
متن کامل